β-Ketophosphonates as substrates in the Biginelli multicomponent reaction: an efficient and straightforward synthesis of phosphorylated dihydropyrimidinones

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Efficient synthesis of dihydropyrimidinones via a three-component Biginelli-type reaction of urea, alkylaldehyde and arylaldehyde

A one-pot three-component synthesis of dihydropyrimidinones via a molecular iodine-catalyzed tandem reaction of simple readily available mono-substituted urea, alkylaldehyde, and arylaldehyde has been developed. The reaction proceeds with high chemo- and regioselectivity to give highly diverse dihydropyrimidinones in reasonable yields under mild reaction conditions. Moreover, the first catalyti...

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ژورنال

عنوان ژورنال: Arkivoc

سال: 2013

ISSN: 1551-7012

DOI: 10.3998/ark.5550190.p007.871